The USA-led imperialist globalization project across the globe has been disrupted by the emerging powers: China-Russia-India-Brazil-South Africa led ‘BRICS’ through ‘One Belt One Road (OBOR)’ and ‘De-dollarization’ Initiatives’ to achieve the goals of ‘Self-reliance’, sustainable development and economic growth, and inclusive multilateralism along-with multi-polarity. In this context, the fourth largest trading and economic bloc AfCFTA attracts the global community for trading and investment in the region. This study reviews China-Africa and India-Africa economic relations along the lines of trade flows (dynamics, structure, and destinations of exports and imports) and foreign direct investment (stocks accumulated in African countries). The author identified the existing problems and challenges of trade and investment integration and revealed opportunities for sustainable and economic growth. The purpose of this study was to fill a gap in academic research to re-investigate the current status and analyse intra-trade performance among AfCFTA countries by using the analytical and statistical methodology of collected secondary data from various sources. Finally, set recommendations and conclusion